Calibration and numerical simulation of Nanoparticle Surface Area Monitor
(TSI Model 3550 NSAM) |
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Authors: | W G> Shin D Y H Pui H Fissan S Neumann A Trampe |
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Institution: | (1) Mechanical Engineering Department, University of Minnesota, Minneapolis, MN, USA;(2) University of Duisburg-Essen, Duisburg, Germany |
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Abstract: | TSI Nanoparticle Surface Area Monitor (NSAM) Model 3550 has been developed to measure the nanoparticle surface area deposited
in different regions of the human lung. It makes use of an adjustable ion trap voltage to match the total surface area of
particles, which are below 100 nm, deposited in tracheobronchial (TB) or alveolar (A) regions of the human lung. In this paper,
calibration factors of NSAM were experimentally determined for particles of different materials. Tests were performed using
monodisperse (Ag agglomerates and NaCl, 7–100 nm) and polydisperse particles (Ag agglomerates, number count mean diameter
below 50 nm). Experimental data show that the currents in NSAM have a linear relation with a function of the total deposited
nanoparticle surface area for the different compartments of the lung. No significant dependency of the calibration factors
on particle materials and morphology was observed. Monodisperse nanoparticles in the size range where the response function
is in the desirable range can be used for calibration. Calibration factors of monodisperse and polydisperse Ag particle agglomerates
are in good agreement with each other, which indicates that polydisperse nanoparticles can be used to determine calibration
factors. Using a CFD computer code (Fluent) numerical simulations of fluid flow and particle trajectories inside NSAM were
performed to estimate response function of NSAM for different ion trap voltages. The numerical simulation results agreed well
with experimental results. |
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Keywords: | nanoparticle surface area deposition in compartments of human lung tracheobronchial alveolar instrumentation occupational health |
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