Intake and excretion of disodium monomethylarsonate in horses: a speciation study |
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Authors: | Roberta A Assis Ivo L Kuchler Norbert Miekeley Marta B Tozzi |
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Institution: | Department of Analytical Chemistry, Fluminense University, Niterói, Brazil. |
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Abstract: | Capillary electrophoresis coupled to inductively coupled plasma mass spectrometry was used in a speciation study on disodium
monomethylarsonate (DS-MMAV) and its metabolites in horses, to which the drug was administered by intramuscular injection on five consecutive days at
a single arsenic dosage of 270 mg day−1. Samples of urine, whole blood, plasma, and mane hair were analyzed before, during, and after drug administration. The data
show that blood clearing and urinary excretion of MMA is a fast process following first-order kinetics with biological half-lives
of about 38 h and 44 h for urine and plasma, respectively. In the time period of 9 days studied, the only metabolite detected
in urine was dimethylarsinic acid (DMAV), which 4 days after the last drug administration accounted for up to 75% of the total excreted arsenic species. This shows,
for the first time, that biomethylation of MMAV to DMAV is the principal metabolic pathway of this drug in horses. Although DS-MMAV was administered only during a short 5-day period, an up to six fold increase of arsenic could be measured in the newly grown
mane hair. |
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Keywords: | Capillary electrophoresis ICPMS Arsenic speciation Biomethylation Horses |
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