| 复方板蓝根颗粒抗病毒成分HPLC-UV指纹图谱及LC-ESI-MSn研究 |
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| 引用本文： | 闫峻,刘舒,皮子凤,宋凤瑞,刘忠英,刘志强. 复方板蓝根颗粒抗病毒成分HPLC-UV指纹图谱及LC-ESI-MSn研究[J]. 化学学报, 2011, 69(2): 204-208 |
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| 作者姓名： | 闫峻 刘舒 皮子凤 宋凤瑞 刘忠英 刘志强 |
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| 作者单位： | (1吉林大学药学院 长春 130021)(2中国科学院长春应用化学研究所 长春 130022) |
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| 基金项目： | 国家“十一五”科技支撑计划(No.2006BAI08B03-02)资助项目 |
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| 摘 要： | 建立了复方板蓝根颗粒提取物高效液相色谱(HPLC-UV)指纹图谱分析方法. 确定了10批不同来源复方板蓝根颗粒提取物的19个共有峰. 各提取物的HPLC-UV指纹图谱与对照指纹图谱比较, 相似度均在93%以上. 利用液相色谱与质谱联用(LC-ESI-MSn)技术对主要共有峰的结构进行了鉴定. 药效学研究表明, 复方板蓝根颗粒提取物有抗病毒活性. 该指纹图谱精密度、稳定性和重现性良好, 可作为复方板蓝根颗粒的质量评价方法.
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| 关 键 词： | 复方板蓝根颗粒 指纹图谱 液相色谱与质谱联用 抗病毒活性 |
Studies on Fingerprint Chromatograms of Anti-virus Component of Compound Indigowoad Root Granule by HPLC-UV and LC-ESI-MSn |
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| Yan Jun,Liu Shu,Pi Zifeng,Song Fengrui,Liu Zhongying,Liu Zhiqiang. Studies on Fingerprint Chromatograms of Anti-virus Component of Compound Indigowoad Root Granule by HPLC-UV and LC-ESI-MSn[J]. Acta Chimica Sinica, 2011, 69(2): 204-208 |
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| Authors: | Yan Jun Liu Shu Pi Zifeng Song Fengrui Liu Zhongying Liu Zhiqiang |
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| Affiliation: | (1 College of Pharmacy, Jilin University, Changchun 130021)(2 Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022) |
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| Abstract: | The fingerprint chromatograms of the extracts from Compound Indigowoad Root Granule was established by HPLC-UV.Nineteen common peaks were found in fingerprint chromatograms of the extracts from Compound Indigowoad Root Granule and good similarities with correlation coefficients over 93% were found between the fingerprint chromatograms of the extracts from different sources.The main common peaks were identificated by HPLC-MSn.Pharmacodynamic studies have shown that the extract from Com-pound Indigowoad Root ... |
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| Keywords: | Compound Indigowoad Root Granule fingerprint chromatograms HPLC-MSn anti-viral ac-tivity |
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