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复方板蓝根颗粒抗病毒成分HPLC-UV指纹图谱及LC-ESI-MSn研究
引用本文:闫峻,刘舒,皮子凤,宋凤瑞,刘忠英,刘志强. 复方板蓝根颗粒抗病毒成分HPLC-UV指纹图谱及LC-ESI-MSn研究[J]. 化学学报, 2011, 69(2): 204-208
作者姓名:闫峻  刘舒  皮子凤  宋凤瑞  刘忠英  刘志强
作者单位:(1吉林大学药学院 长春 130021)(2中国科学院长春应用化学研究所 长春 130022)
基金项目:国家“十一五”科技支撑计划(No.2006BAI08B03-02)资助项目
摘    要:建立了复方板蓝根颗粒提取物高效液相色谱(HPLC-UV)指纹图谱分析方法. 确定了10批不同来源复方板蓝根颗粒提取物的19个共有峰. 各提取物的HPLC-UV指纹图谱与对照指纹图谱比较, 相似度均在93%以上. 利用液相色谱与质谱联用(LC-ESI-MSn)技术对主要共有峰的结构进行了鉴定. 药效学研究表明, 复方板蓝根颗粒提取物有抗病毒活性. 该指纹图谱精密度、稳定性和重现性良好, 可作为复方板蓝根颗粒的质量评价方法.

关 键 词:复方板蓝根颗粒  指纹图谱  液相色谱与质谱联用  抗病毒活性  

Studies on Fingerprint Chromatograms of Anti-virus Component of Compound Indigowoad Root Granule by HPLC-UV and LC-ESI-MSn
Yan Jun,Liu Shu,Pi Zifeng,Song Fengrui,Liu Zhongying,Liu Zhiqiang. Studies on Fingerprint Chromatograms of Anti-virus Component of Compound Indigowoad Root Granule by HPLC-UV and LC-ESI-MSn[J]. Acta Chimica Sinica, 2011, 69(2): 204-208
Authors:Yan Jun  Liu Shu  Pi Zifeng  Song Fengrui  Liu Zhongying  Liu Zhiqiang
Affiliation:(1 College of Pharmacy, Jilin University, Changchun 130021)(2 Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022)
Abstract:The fingerprint chromatograms of the extracts from Compound Indigowoad Root Granule was established by HPLC-UV.Nineteen common peaks were found in fingerprint chromatograms of the extracts from Compound Indigowoad Root Granule and good similarities with correlation coefficients over 93% were found between the fingerprint chromatograms of the extracts from different sources.The main common peaks were identificated by HPLC-MSn.Pharmacodynamic studies have shown that the extract from Com-pound Indigowoad Root ...
Keywords:Compound Indigowoad Root Granule  fingerprint chromatograms  HPLC-MSn  anti-viral ac-tivity  
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