Cycloaromatization protocol for synthesis of polysubstituted phenol derivatives: method development and mechanistic studies |
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Authors: | William T Spencer Alison J Frontier |
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Institution: | Department of Chemistry, University of Rochester , Rochester, New York 14627, United States. |
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Abstract: | The scope of the cycloaromatization of propargylic ethers was explored using operationally simple air- and moisture-insensitive conditions. Highly substituted phenol derivatives were obtained in high yields. Mechanistic experiments indicate that the reaction occurs by an electrocyclization followed by 1,3-proton transfer. |
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