Camphor-derived C(1)-symmetric chiral diamine organocatalysts for asymmetric Michael addition of nitroalkanes to enones |
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| Authors: | Yirong Zhou Qiang Liu Yuefa Gong |
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| Institution: | School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, People's Republic of China. gongyf@mail.hust.edu.cn. |
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| Abstract: | A series of stable C(1)-symmetric chiral diamines () were conveniently synthesized by condensing exo-(-)-bornylamine or (+)-(1S,2S,5R)-menthylamine with various commercially available Cbz-protected amino acids. Among them, can efficiently promote the Michael addition of nitroalkanes to a broad scope of enones with high yields (up to 96%) and excellent enantioselectivities (up to 98%) under mild conditions. |
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