Enantioselective Diels-Alder Reactions with G-Quadruplex DNA-Based Catalysts |
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| Authors: | Changhao Wang Guoqing Jia Jun Zhou Yinghao Li Yan Liu Shengmei Lu Can Li |
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| Affiliation: | State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023 (China) http://www.canli.dicp.ac.cn. |
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| Abstract: | DNA in command: An enantioselective Diels-Alder reaction can be achieved using human telomeric G-quadruplex DNA-based catalysts. The absolute configuration of the product can be reversed when the conformation of G-quadruplex DNA is switched from antiparallel to parallel, and both the reaction rate and the enantioselectivity of the Diels-Alder reaction were found to be dependent on the DNA sequence. |
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| Keywords: | asymmetric catalysis cycloaddition Diels–Alder reaction DNA sequence‐dependence |
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