Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain |
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| Authors: | Pieter Van de Vijver Liesbeth Scheer Judy van Beijnum Arjan Griffioen Tilman M Hackeng |
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| Affiliation: | Laboratory for Chemical Protein Synthesis, Department of Biochemistry, Maastricht University, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands. p.vandevijver@maastrichtuniversity.nl t.hackeng@maastrichtuniversity.nl. |
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| Abstract: | The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain. |
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