Facile synthesis of sterically hindered and electron-deficient secondary amides from isocyanates |
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Authors: | Gabriel Schäfer Coraline Matthey Jeffrey W Bode |
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Affiliation: | Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich (Switzerland) http://www.bode.ethz.ch. |
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Abstract: | The big easy: The direct coupling of Grignard reagents to isocyanates provides a facile and robust solution for the synthesis of sterically hindered and electron-deficient secondary amides. The products are obtained in high yields without the need for excess reagents or chromatographic purification. |
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Keywords: | amides C?C coupling Grignard reaction isocyanates steric hindrance |
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