Efficient Total Synthesis of (S)-Dihydroresorcylide, a Bioactive Twelve-Membered Macrolide |
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| Authors: | Li Zhang Wenquan Ma Lili Xu Fei Deng Yuewei Guo |
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| Affiliation: | 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
2. Biomedical Science Park of Weifang, Weifang National High-Tech Industrial Development Zone, Weifang, Shandong 261205, China |
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| Abstract: | The efficient synthesis of (S)‐dihydroresorcylide ( 1a ) along with trans‐resorcylide dimethyl ether ( 2b ), was achieved in linear 9 steps from commercially available orcinol monohydrate ( 6 ) with esterification, carbonylation, and ring‐closing metathesis (RCM) as the key steps in the synthetic sequence. |
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| Keywords: | dihydroresorcylide trans-resorcylide dimethyl ether ring-closing metathesis (RCM) carbonylation total synthesis |
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