Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation |
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| Authors: | Hong Cheol Am Lee Soo Hyeon Kim Jee Seon Park Ji Won Bae Ki Hyun Mok Hyejung Park Tae Gwan Lee Haeshin |
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| Affiliation: | Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea. |
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| Abstract: | The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity. |
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