Determination of Enantiomeric Excess of Leucine by 13C CP-MAS Solid-State NMR

The enantiomeric excess can be determined by many methods. One of them is nuclear magnetic resonance in solid state (SS-NMR). In this study we used the SS-NMR experiment of one-dimensional exchange spectroscopy by sideband alteration for determination of the enantiomeric excess of leucine. The density functional theory gauge-including atomic orbital calculations were used to assign all signals in ¹³C cross polarization magic-angle spinning spectra for two different molecules in the crystal lattice of L-leucine. Authors' address: Elżbieta J. Tadeusiak, Department of Structural Studies, Center of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland