Investigation of surface plasmon biosensing using gold nanoparticles enhanced ellipsometry |
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Authors: | Moirangthem Rakesh Singh Chang Yia-Chung Wei Pei-Kuen |
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Institution: | Research Centre for Applied Sciences, Academia Sinica, Taipei, Taiwan. |
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Abstract: | We present a label-free, nondestructive and high sensitivity biosensor by using the phase information of a gold nanoparticles enhanced ellipsometry signal. The refractive index (RI) resolution from ellipsometric phase information is of the order of 1.6×10(-6) RI units. Furthermore, spectroscopic and dynamic measurements show substantial change in the phase signal when biomolecules are coated on gold nanoparticles. The detection limit of our proposed technique is up to ~18?pM concentration of the target biomolecules. |
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