| (±)-16-羟基-6,7-脱氢铁锈醇甲醚及其类似物的合成 |
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| 引用本文： | 沈灏,李安排,王晖,杜振亭,武同兴,潘鑫复.(±)-16-羟基-6,7-脱氢铁锈醇甲醚及其类似物的合成[J].高等学校化学学报,2003,24(2):270-273. |
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| 作者姓名： | 沈灏 李安排 王晖 杜振亭 武同兴 潘鑫复 |
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| 作者单位： | 兰州大学化学系, 应用有机化学国家重点实验室, 兰州 730000 |
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| 基金项目： | 国家自然科学基金 (批准号 :2 9772 0 15 )资助 |
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| 摘 要： | 采用AC→ABC的合成策略,以α-环柠檬醛为A环起始原料,通过与C环化合物8缩合、选择性还原及分子内环合得到关键中间体11,再经过官能团修饰和转换,合成了16-羟基-6,7-脱氢铁锈醇甲醚及其3个类似物.
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| 关 键 词： | 三环二萜 铁锈醇 柳杉酚 |
| 文章编号： | 0251-0790(2003)02-0270-04 |
| 收稿时间： | 2001-12-05 |
| 修稿时间： | 2001年12月5日 |
Synthesis of 16-Hydroxy-6,7-didehydraferruginyl Methyl Ether and Its Analogues with 16-Oxidant Group |
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| SHEN Hao,LI An-Pai,WANG Hui,DU Zhen-Ting,WU Tong-Xing,PAN Xin-Fu.Synthesis of 16-Hydroxy-6,7-didehydraferruginyl Methyl Ether and Its Analogues with 16-Oxidant Group[J].Chemical Research In Chinese Universities,2003,24(2):270-273. |
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| Authors: | SHEN Hao LI An-Pai WANG Hui DU Zhen-Ting WU Tong-Xing PAN Xin-Fu |
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| Institution: | National Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, China |
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| Abstract: | The synthetic strategy of AC→ABC was used, in which α-cyclocitral was used as A ring synthon. The key intermediate 11 was obtained after condensation of α-cyclocitral with triphenyl phosphonium chloride 8, sequently selective reduction by Pd/C and intramolecular cyclization. 16-Hydroxy-6,7-didehy-draferruginyl methyl ether and three analogues with 16-oxidant group were synthesized from this key intermediate via structure modification. |
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| Keywords: | Tricyclic diterpenoid Ferruginol Suginyl phenol |
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