高分子手性固定相的研究进展

手性药物的应用对人类健康产生了深远影响。随着化学、材料、生命等学科的发展,人们对手性药物分离分析的研究日趋深入。色谱法在手性药物分离分析中得到了广泛应用,手性固定相的选择是实现手性色谱拆分的关键。以高分子材料作为手性固定相并对其进行衍生以优化手性分离性能是近些年的研究热点。本文介绍了近几年高分子手性固定相在手性分离中的研究进展,并对其发展前景进行了展望。

Advances in polymer materials as chiral stationary phase

The applications of chiral drugs had a profound impact on human health. With the development of disciplines of chemistry, materials and life science, the research on the separation and analysis of chiral drugs became intensified. Chromatography and the selection of chiral stationary phase played important roles in resolving chiral drugs. The optimization of polymer materials and their derivatives as chiral stationary phase become the main issue in recent years. Recent studies as well as prospects in polymer materials used as chiral stationary phase are presented in this paper.