Synthesis of 1,2,4-oxadiazines and their rearrangement to pyrimidines |
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Authors: | Arthur A Santilli Anthony C Scotese |
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Abstract: | Several amide oximes underwent condensation reactions with dimethyl acetylene dicarboxylate to afford 1:1 adducts. Under basic conditions, these adducts underwent ring closure to afford several methyl 3-(substituted)-4,5-dihydro-5-oxo-6H-1,2,4-oxadiazin-6-ylidene]acetates. The reactions of these compounds with a variety of amines resulted in addition-rearrangement reactions with the formation of the corresponding methyl 2-substituted-5-substituted amino-1,6-dihydro-6-oxo-4-pyrimidine carboxylates. |
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