Nickel-catalyzed enantioselective alkylative coupling of alkynes and aldehydes: synthesis of chiral allylic alcohols with tetrasubstituted olefins |
| |
| Authors: | Yang Yun Zhu Shou-Fei Zhou Chang-Yue Zhou Qi-Lin |
| |
| Affiliation: | State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China. |
| |
| Abstract: | A highly efficient nickel-catalyzed asymmetric alkylative coupling of alkynes, aldehydes, and dimethylzinc has been realized by using bulky spirobiindane phosphoramidite ligands, affording allylic alcohols with a tetrasubstituted olefin functionality in high yields, high regioselectivities, and excellent enantioselectivities. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
