Catalytic asymmetric intermolecular Stetter reaction of glyoxamides with alkylidenemalonates |
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Authors: | Liu Qin Perreault Stéphane Rovis Tomislav |
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Institution: | Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA. |
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Abstract: | An asymmetric intermolecular Stetter reaction of glyoxamide and alkylidenemalonates has been developed. Catalyzed by a novel N-heterocyclic carbene, the Stetter adducts are formed in good yield and excellent enantioselectivity. The presence of a sensitive epimerizable stereocenter is tolerated under these mildly basic reaction conditions if a bulky amine base is used. The products may be further elaborated to provide synthetically useful intermediates. |
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