Synthesis of beta-, gamma-, and delta-lactams via Pd(II)-catalyzed C-H activation reactions |
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| Authors: | Wasa Masayuki Yu Jin-Quan |
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| Institution: | Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
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| Abstract: | Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams. |
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