改良的橘皮果胶抑制半乳糖凝集素-3与肿瘤相关功能的研究进展

半乳糖凝集素-3(Gal-3)是半乳糖凝集素家族中唯一一种嵌合体结构蛋白,含有一个特定的糖基识别结构域(CRD),能够特异性识别并结合半乳糖,此结构域可介导细胞与细胞之间的黏附和识别,并且能够促进部分肿瘤细胞的增殖和转移等。改良的橘皮果胶(MCP)可通过特异性结合肿瘤相关蛋白Gal-3糖基识别结构域,抑制Gal-3与其相关肿瘤受体的结合,阻断肿瘤细胞之间相关信号的传导,从而表现出较强的抗肿瘤活性。本文综述了MCP在Gal-3介导肿瘤发生发展过程中相关作用的研究进展。

Research progress of modified citrus pectin on inhibiting galectin-3 function related on tumor

Galectin-3 (Gal-3) is the only chimeric structural protein in the galectin family and contains a specific carbohydrate recognition domain (CRD) that can specifically recognize and bind galactose. The CRD can mediate cell-cell adhesion and recognition and can promote the proliferation and metastasis of some tumor cells. Modified citrus pectin (MCP) can specifically inhibit the binding of Gal-3 to its related tumor receptors by interacting with the tumor-associated protein Gal-3 to block the related signals between tumor cells conduction, thus showing strong antitumor activities. This study reviews the research progress of MCP on Gal-3-mediated tumorigenesis and development.