Amidomethylation of phenanthridines: Synthesis and structure determination by 1H NMR

Phenanthridine reacts with N-(hydroxymethyl)phthalimide to give, in two steps, three monosubstituted aminomethylphenanthridines. The three isomers were separated by chromatography on silica gel. The position of substitution was determined using one- and two-dimensional ¹H nmr methods.