Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini |
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Authors: | Liu Yu Kuzuya Akinori Sha Ruojie Guillaume Johan Wang Risheng Canary James W Seeman Nadrian C |
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Institution: | Department of Chemistry, New York University, New York, New York 10003, USA. |
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Abstract: | We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies. |
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