Application of the combined C-H activation/Cope rearrangement as a key step in the total syntheses of the assigned structure of (+)-elisabethadione and a (+)-p-benzoquinone natural product |
| |
| Authors: | Huw ML Davies Xing Dai |
| |
| Institution: | Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA |
| |
| Abstract: | The enantioselective total syntheses of the assigned structure of (+)-elisabethadione (3) and the (+)-p-benzoquinone natural product 4 is described. The stereocontrolled formation of the three key stereocenters in the natural products is achieved in a single step through the combined C-H activation/Cope rearrangement, a C-H functionalization process catalyzed by the dirhodium tetraprolinate, Rh2(R-DOSP)4 (DOSP=(N-dodecylbenzenesulfonyl)prolinate). |
| |
| Keywords: | Combined C-H activation/Cope rearrangement Total synthesis 3)" target="_blank">(+)-Elisabethadione (3) Rhodium carbenoid C-H insertion |
| 本文献已被 ScienceDirect 等数据库收录！ |
