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Stereoselective syntheses of (−)-chloramphenicol and (+)-thiamphenicol |
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| Authors: | Saumen Hajra Ananta Karmakar Tapan Maji Amiya Kumar Medda |
| Affiliation: | Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India |
| Abstract: | Chloramphenicol and thiamphenicol have been enantioselectively synthesized using an asymmetric halohydrin reaction as a key step. In particular, halomethoxylation reaction was used, where O-methyl functions as a hydroxyl protecting group and eliminates an additional protection step. |
| Keywords: | Enantioselective synthesis (&minus )-Chloramphenicol (+)-Thiamphenicol Asymmetric Halohydrin reaction |
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