a Institute of Chemistry, University of São Paulo, São Paulo, SP 05508-900, Brazil b Amazon Biotechnology Center, Manaus, MA 69075-351, Brazil c Center for Applied Toxinology, Butantan Institute, São Paulo, SP 05503-900, Brazil
Abstract:
An efficient and versatile synthesis of acylpolyamine spider toxins of all structural types classified by extensive MS analysis has been achieved. By using 2-nitrobenzenesulfonamide as an effective activating and/or protecting group (the Nosyl strategy), the naturally occurring toxins 1-8 corresponding to Types A-F were concisely synthesized in high overall yield.