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An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins
Authors:Ken-ichi Nihei  Massuo J. Kato  Katsuhiro Konno
Affiliation:a Institute of Chemistry, University of São Paulo, São Paulo, SP 05508-900, Brazil
b Amazon Biotechnology Center, Manaus, MA 69075-351, Brazil
c Center for Applied Toxinology, Butantan Institute, São Paulo, SP 05503-900, Brazil
Abstract:An efficient and versatile synthesis of acylpolyamine spider toxins of all structural types classified by extensive MS analysis has been achieved. By using 2-nitrobenzenesulfonamide as an effective activating and/or protecting group (the Nosyl strategy), the naturally occurring toxins 1-8 corresponding to Types A-F were concisely synthesized in high overall yield.
Keywords:Acylpolyamine   Spider toxins   Ns strategy   Structural classification   Versatile synthesis
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