An easy and general protocol for multicomponent coupling reactions of aldehydes, amides, and dienophiles |
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Authors: | Dirk Strü bing |
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Affiliation: | Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany |
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Abstract: | An improved procedure for the three-component coupling reaction of aldehydes, amides, and dienophiles (AAD-reaction) has been developed. The use of microwave technology enables the endo-selective synthesis of N-acyl cyclohexenylamines via condensation of readily available aldehydes and amides, and subsequent Diels-Alder reaction with electron-deficient dienophiles in significantly improved yields. Advantageously, there is no need of employing additional solvents and reaction times are drastically reduced compared to similar thermal reactions. |
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Keywords: | Aldehydes Dienophiles Diels-Alder reaction Multicomponent reaction Microwaves |
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