Chemical predisposition in synthesis: application to the preparation of the pyrrolidine natural products, plakoridines A and B |
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| Authors: | Laura L. Etchells Roger C. Whitehead |
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| Affiliation: | The School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK |
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| Abstract: | The pyrrolidine natural products, plakoridines A and B, as well as an array of unnatural analogues, have been prepared using a five-step synthetic sequence modelled on a biogenetic theory. The key transformation involves a ‘Mannich/Michael/internal-redox’ cascade, which proceeds in yields of 31-63%. |
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