One-step three-component coupling of aromatic organozinc reagents, secondary amines, and aromatic aldehydes into functionalized diarylmethylamines |
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| Authors: | Erwan Le Gall,Michel Troupel,Jean-Yves Né dé lec |
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| Affiliation: | Laboratoire d'Electrochimie, Catalyse et Synthèse Organique (LECSO), CNRS-Université Paris 12 Val de Marne, UMR 7582, 2-8 rue Henri Dunant, 94320 Thiais, France |
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| Abstract: | Numerous functionalized diarylmethylamines have been synthesized in high yield according to a one-step three-component coupling between an aromatic organozinc reagent, a secondary amine, and an aromatic aldehyde. Both organozinc species and aldehyde can bear a functional group and either aromatic or non-aromatic amines can be used in this versatile procedure. |
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| Keywords: | Diarylmethylamines Multi-component reaction Aromatic organozinc reagents Aromatic aldehydes Secondary amines |
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