Synthesis of 6- and 7-acyl-4H-benzothiazin-3-ones |
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Authors: | Pascal Carato Ziaeddine Moussavi Nicolas Lebegue Saïd Yous |
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Institution: | a Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, EA 1043, 3, rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France b Faculty of Pharmacy, Salman Street, Sari, Iran |
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Abstract: | Synthesis of 6- and 7-substituted benzoxazin-3-ones was already described in the literature by acylation of the corresponding benzoxazin-3-ones or cyclization of the corresponding 4- or 5-acyl-2-aminophenols. This paper describes original synthetic pathways to afford the 6- and 7-acyl products in the benzothiazin-3-one series, respectively, via Stille coupling reaction and by acylation. |
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Keywords: | Benzothiazin-3-one Friedel-Crafts acylation Stille coupling |
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