PdCl<sub>2</sub>/CuCl<sub>2</sub>-catalysed chlorocyclisation of sugar-derived aminoalkenitols in the synthesis of new iminohexitols期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

PdCl₂/CuCl₂-catalysed chlorocyclisation of sugar-derived aminoalkenitols in the synthesis of new iminohexitols

Authors:	Peter Szolcsá nyi^{,Tibor Gracza}

Affiliation:	Department of Organic Chemistry, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovakia

Abstract:	The total synthesis of two novel l-ido and l-altro configured 6-chloro-1,5,6-trideoxyiminohexitols featuring a highly diastereoselective Pd(II)/CuCl₂-catalysed chlorocyclisation of sugar-derived aminoalkenitols has been accomplished. The requisite substrates were, in turn, prepared from chiral pool materials starting from the cheap and commercially available methyl-α-d-gluco- and methyl-α-d-galactopyranoside.

Keywords:	Palladium catalysis Copper(II) chloride Aminoalkenitols Azasugars Chlorocyclisation Total synthesis
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