Synthesis of enantiopure 1-substituted, 1,2-disubstituted, and 1,4,5-trisubstituted imidazoles from 1,2-amino alcohols |
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| Authors: | Yuki Matsuoka Daisuke Sasaki |
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| Institution: | Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-8656, Japan |
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| Abstract: | A highly versatile method for the preparation of enantiopure 1-substituted, 1,2-disubstituted, and 1,4,5-trisubstituted imidazoles was developed by using the cyclocondensation reaction of a 1,2-dicarbonyl compound, an aldehyde, a 1,2-amino alcohol, and ammonium acetate. |
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| Keywords: | 1 2-Amino alcohol Chiral pool Cyclocondensation Enantiopure N-Substituted imidazole |
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