1-Aryltetralin privileged structure-based libraries: parallel synthesis of <em>N</em>-aryl and <em>N</em>-biaryl γ-lactam lignans期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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1-Aryltetralin privileged structure-based libraries: parallel synthesis of N-aryl and N-biaryl γ-lactam lignans

Authors:	Matthieu Dorbec Claude Monneret Emmanuel Bertounesque

Institution:	^a UMR 176 CNRS-Institut Curie, Centre de Recherche, 26 rue d'Ulm, 75248 Paris Cedex 05, France ^b Département de RMN, Ecole Nationale Supérieure de Chimie de Paris, 11 rue P. et M. Curie, 75231 Paris Cedex 05, France

Abstract:	The parallel solution-phase synthesis of two libraries of product-like compounds derived from a 1-aryltetralin privileged structure is described. The N-aryl picropodophyllone γ-lactams were synthesized from methyl ester thuriferic acid via InCl₃-tandem aza-Michael addition-cyclization reaction of anilines. Bromo-aryl compounds from this library were subjected to a ligandless palladium Suzuki cross-coupling to give the expected N-biaryl picropodophyllin γ-lactams.

Keywords:	Biaryls Lactam lignans Privileged structure Tandem reaction InCl₃ Ligandless Suzuki reaction Parallel solution-phase synthesis
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