An advantageous synthesis of new indazolone and pyrazolone derivatives |
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Authors: | Arkaitz Correa Esther Domínguez Raul SanMartin |
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Institution: | Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco-Euskal Herriko Unibertsitatea, PO Box 644, 48080 Bilbao, Spain |
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Abstract: | The synthesis of new indazolone and pyrazolone derivatives starting from methyl anthranilate type substrates is presented. This general approach constitutes a novel and advantageous alternative for the synthesis of the target heterocycles, which implies the use of the environmentally friendly oxidizer PIFA. The synthetic design includes the oxidation of N-arylamides by the hypervalent iodine reagent to the corresponding N-acylnitrenium ions, which can be intramolecularly trapped by an amine moiety to furnish the title compounds by formation of a new N-N single bond. |
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Keywords: | Hypervalent iodine N-Acylnitrenium Indazolone Pyrazolone |
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