A concise synthesis of nornitidine via nickel- or palladium-catalyzed annulation |
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| Authors: | Yu Luo Yuhua Mei Wei Lu Jie Tang |
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| Affiliation: | a Institute of Medicinal Chemistry, Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, Shanghai 200062, China
b Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | A concise method to synthesize benzo[c]phenanthridine alkaloid, nornitidine, was developed utilizing nickel- or palladium-catalyzed iminoannulation of an internal alkyne. The advantages of this strategy included readily available starting materials, inexpensive reagents, short reaction steps, and good yields. |
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| Keywords: | Benzo[c]phenanthridine Isoquinolines Nitidine Palladium Nickel Catalysis |
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