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Synthesis of a hydrophilic and non-ionic anthracene derivative, the N,N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide as a chemical trap for singlet molecular oxygen detection in biological systems |
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| Authors: | Glaucia R Martinez Flávia Garcia Jean Cadet Graziella E Ronsein Marisa HG Medeiros |
| Institution: | a Departamento de Bioquímica e Biologia Molecular, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba-PR, Brazil b Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil c Laboratoire ‘Lésions des Acides Nucléiques’, DRFMC/LCIB-UMR-E n°3 (CEA/UJF), CEA/Grenoble, F-38054 Grenoble cedex 9, France d Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26.077, 05513-970 São Paulo, SP, Brazil |
| Abstract: | We report herein the synthesis of a new hydrophilic and non-ionic anthracene derivative, the N,N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide. The evaluation of this compound as chemical trap of singlet molecular oxygen by using labeling experiments and HPLC-MS analysis showed that it could be efficiently used in biological investigations. |
| Keywords: | Anthracene Endoperoxide HPLC-MS Singlet oxygen Trap Probe |
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