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Synthesis of novel poly(ethylene glycol) supported benzazepines: the crucial role of PEG on the selectivity of an intramolecular Heck reaction |
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| Authors: | Patrice Ribiè re,Yannig Né dellec,Jean Martinez |
| Affiliation: | a Laboratoire des Aminoacides, Peptides et Protéines (LAPP), CNRS-Universités Montpellier 1 et 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France b Laboratoire des Agrégats Moléculaires et Matériaux Inorganiques (LAMMI), CNRS-Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France c Aventis Pharma, 102 route de Noisy, 93325 Romainville Cedex, France |
| Abstract: | Poly(ethylene glycol) (PEG 3400) was used as a soluble polymeric support for the synthesis of a series of novel benzazepines. The key step for the preparation of these heterocycles was a phosphine-free palladium-catalyzed Heck reaction. Palladium nanoparticles formed during the course of the reaction were characterized. The presence of PEG 3400 influenced the outcome of the reaction in terms of selectivity. |
| Keywords: | Polymer supported chemistry Heterocycles Heck reaction Nanoparticles Immobilization Palladium Solvent effects |
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