Synthesis of β-amino carbonyl compounds via a Zn(OTf)2-catalyzed cascade reaction of anilines with aromatic aldehydes and carbonyl compounds |
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Authors: | Yun-Yun Yang |
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Institution: | Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China |
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Abstract: | A Zn(OTf)2-catalyzed cascade reaction of anilines with aromatic aldehydes and carbonyl compounds was described. This one-pot three-component reaction afforded the corresponding β-amino carbonyl compounds, β-amino esters, and β-amino ketones in good to excellent yields. The reaction was also applied for the liquid-phase synthesis of β-amino carbonyl compound library using PEG as a support. |
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Keywords: | β-Amino esters β-Amino ketones Cascade reaction Mannich reactions |
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