Pd(OAc)2/DABCO-catalyzed Suzuki-Miyaura cross-coupling reaction in DMF |
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| Authors: | Jin-Heng Li Qi-Ming Zhu Ye-Xiang Xie |
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| Affiliation: | Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China |
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| Abstract: | The scope and limitations of the Pd(OAc)2/DABCO (1,4-diaza-bicyclo[2.2.2]octane)-catalyzed Suzuki-Miyaura cross-coupling reactions have been demonstrated. The results showed that the effect of solvent had a fundamental influence on the reaction. In the presence of Pd(OAc)2 and DABCO, both aryl bromides and aryl chlorides all worked well with arylboronic acids to form biaryls, heteroaryl-aryls, and biheteroaryls in moderate to excellent yields using DMF as the solvent. Additionally, the reactions of aryl bromides were conducted under relatively mild conditions. |
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| Keywords: | Pd(OAc)2/DABCO Suzuki-Miyaura cross-coupling reaction Aryl halide Arylboronic acids |
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