Synthesis of 4,5-diaminopyrrolo[1,2-a]quinoline derivatives by annulation of N,N-dialkyl[2-(pyrrol-1-yl)benzylidene]ammonium salts in the presence of an isocyanide |
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| Authors: | Kazuhiro Kobayashi Atsushi Takanohashi Kenichi Hashimoto Osamu Morikawa Hisatoshi Konishi |
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| Affiliation: | Department of Materials Science, Faculty of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan |
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| Abstract: | A facile synthetic method for 4,5-diaminopyrrolo[1,2-a]quinoline derivatives has been developed. Treatment of 2-(pyrrol-1-yl)benzaldehydes with secondary amine hydrochloride/NaI/TMSCl/Et3N in the presence of an isocyano compound leads to the formation of 4-alkyl(or aryl)amino-5-dialkylaminopyrrolo[1,2-a]quinolines. |
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| Keywords: | Iminium salt Isocyanide Pyrrole Pyrroloquinoline Secondary amine |
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