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Silver(I) complexes based on novel tripodal thioglycosides: synthesis, structure and antimicrobial activity |
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| Authors: | Michael Gottschaldt Annett Pfeifer Helmar Görls Ute Möllmann Shigenobu Yano |
| Institution: | a Institute for Organic and Macromolecular Chemistry, Friedrich Schiller University of Jena, Humboldtstrasse 10, 07743 Jena, Germany b Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University of Jena, Lessingstrasse 8, 07743 Jena, Germany c Leibnitz-Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Beutenbergstrasse 11a, 07745 Jena, Germany d Division of Material Science, Graduate School of Human Culture, Nara Women's University, Kitauoyanishimachi, Nara 630-8506, Japan |
| Abstract: | The reaction of tris(2-bromoethyl)amine hydrobromide with sugar thiols or thioacetates leads to the formation of novel carbohydrate substituted tripodal NS3 ligands. Complexation with silver(I) ions gives stable complexes. NMR, X-ray, MS and EXAFS studies indicate their mononuclear C3-symmetric structure. The highly water soluble complexes formed from the unprotected ligands show a wide spectrum of effective antimicrobial activities and their use lowers the cytotoxic and antiproliferative activities compared to the free silver salts. |
| Keywords: | Carbohydrates Silver S-Ligand Biological activity |
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