Synthesis of chlorine-containing angucycline BE-23254 and its analogs |
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Authors: | Dipakranjan Mal |
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Institution: | Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, West Bengal, India |
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Abstract: | The total synthesis of BE-23254, an unusual angucycline antibiotic is reported. This is achieved by adopting a Hauser annulation and a DDQ-promoted aromatization as the key steps. The strategy has been generalized for the synthesis of several analogs of the target molecule. A regioselective preparation of chlorine-containing phenols is also described. |
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Keywords: | Angucyclines Hauser annulation Naphthalenone Chlorinative aromatization |
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