| 豆腐果苷-咪唑衍生物的合成及镇静活性研究 |
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| 引用本文： | 吕世明,杨聪玲,赵辉,李颖,尹述凡.豆腐果苷-咪唑衍生物的合成及镇静活性研究[J].有机化学,2010,30(1):112-116. |
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| 作者姓名： | 吕世明 杨聪玲 赵辉 李颖 尹述凡 |
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| 作者单位： | 四川大学化学学院,成都,610064 |
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| 摘 要： | 以豆腐果苷、2-羟基-1,2-二芳基乙酮(2a～2d)、乙酸铵和脂肪胺为原料,碘单质作为催化剂,成功地合成了一系列豆腐果苷-咪唑类衍生物4a～4h,新化合物4a～4h的结构经~1H NMR,~(13)C NMR,IR和HRMS确认.并用小白鼠实验对目标化合物4a～4h进行了镇静活性筛选,其中4e(400mg·kg~(-1))与豆腐果苷相比有较强的镇静活性.
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| 关 键 词： | 豆腐果苷 咪唑衍生物 2-羟基-1 2-二芳基乙酮 碘 镇静活性 合成 |
| 收稿时间： | 2009-04-04 |
| 修稿时间： | 2009-06-13 |
Synthesis and Calm Activity of Imidazole Derivatives of Helicid |
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| LU Shiming,Yang Congling,Zhao Hui,Li Ying,Yin Shufan.Synthesis and Calm Activity of Imidazole Derivatives of Helicid[J].Chinese Journal of Organic Chemistry,2010,30(1):112-116. |
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| Authors: | LU Shiming Yang Congling Zhao Hui Li Ying Yin Shufan |
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| Institution: | (College of Chemistry，Sichuan University，Chengdu 610064) |
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| Abstract: | A convenient approach for synthesis of the imidazole derivatives of helicid 4a～4h is presented via condensation of helicid,2-hydroxy-1,2-diarylethanone(2a～2d),ammonium acetate and alkyl amine,using iodine as efficient catalyst.The structures of the target compounds 4a～4h were characterized by ~1H NMR,~(13)C NMR,IR and HRMS techniques.Their calm activities were investigated in healthy mice,and compound 4e showed favorable calm activity compared with helicid. |
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| Keywords: | helicid imidazole derivative 2-hydroxy-1 2-diarylethanone iodine calm activity synthesis |
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