| 绞股蓝对明矾诱发遗传物质损伤的抑制作用 |
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| 引用本文： | 钱晓薇,杨明璋,韩安垒.绞股蓝对明矾诱发遗传物质损伤的抑制作用[J].浙江大学学报(理学版),1999,26(4):84-87. |
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| 作者姓名： | 钱晓薇 杨明璋 韩安垒 |
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| 作者单位： | 钱晓薇 温州师范学院生物系，浙江 温州 325027 杨明璋 温州市苍南县龙港三中，浙江 温州 325800 韩安垒 温州市苍南县宜山一中，浙江 温州 325800 |
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| 摘 要： | 本次遗传毒理实验以绞股蓝为材料，以明矾为诱变剂，以小白鼠骨髓嗜多染红细胞的微核率和染色体畸变率作为DNA损伤的指标。结果含10%的绞股蓝饲料使明矾诱变的微核率从8.83±1.7‰降到3.67±0.52‰(P＜0.001)，染色体畸变率从14.17±0.98%降至5.67±1.37%(P＜0.001)。表明绞股蓝对明矾诱发的DNA损伤具有明显的抑制作用，提示绞股蓝具有抗癌作用。
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| 关 键 词： | 绞股蓝 明矾 微核 染色体畸变 |
| 收稿时间： | 1998-11-05 |
Inhibitory Effect of Gynostemma Penlaphyllum on Damaged Genetic Material Caused by Alum. |
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| QIAN Xiao-wei,YANG Min-zhang,HAN An-lei.Inhibitory Effect of Gynostemma Penlaphyllum on Damaged Genetic Material Caused by Alum.[J].Journal of Zhejiang University(Sciences Edition),1999,26(4):84-87. |
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| Authors: | QIAN Xiao-wei YANG Min-zhang HAN An-lei |
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| Institution: | QIAN Xiao-wei1,YANG Min-zhang2,HAN An-lei3 (1.Department of Biology,Wenzhou Normal College,Wenzhou 325027,China;2.Longgang Third Middle School,Wenzhou 325800,China;3.Yishan First Middle School,Wenzhou 325800,China) |
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| Abstract: | In the experiment of poisonousness mechanism in heredity, Gynostemma penlaphyllum was used as material,alum as the mutagen.The rate of micronucleus of the red blood cells with polychromasia and the rate of chromosome aberration was used as the guideline of DNA damage.The result was that the feed containing 10% Gynostemma penlaphyllum made the rate of micronucleus decline from 8.83±1.7‰ to 3.67±0.52‰ (P＜0.001),the rate of chromosome aberration decline from 14.17±0.98% to 5.67±1.37% (P＜0.001).The result showed that the Gynostemma penlaphyllum could inhibit damaged DNA initiated with alum.So the Gynostemma penlaphyllum may resist cancer. |
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| Keywords: | Gynostemma penlaphyllum alum micronucleus chromosome aberration |
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