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Synthesis and Hemolytic Properties of Glycyrrhetic Acid Glycosides
Authors:Nisar Ullah  Werner Seebacher  Robert Weis  Johann Jurenitsch  Katharina Rauchensteiner  Ernst Haslinger
Affiliation:(1)  Institute of Pharmaceutical Chemistry, University of Graz, Graz, Austria, AT;(2)  Institute of Pharmacognosy, University of Vienna, Vienna, Austria, AT
Abstract:Summary.  The synthesis of monodesmosidic glycyrrhetic acid disaccharides via its diphenylmethyl ester is described. Their hemolytic activity is lower as compared to the corresponding oleanolic aciddisaccharides. The influence of the structure of the aglycon on the hemolytic activity is discussed. Received November 18, 1999. Accepted November 30, 1999
Keywords:.   Hemolytic activity   Glycosidation   Glycyrrhetic acid   Disaccharides.
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