| Synthesis and Antitumor Activity of Tanshinone Analogues |
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| 引用本文： | 阿吉艾克拜尔·艾萨,吕伟,蔡俊超. Synthesis and Antitumor Activity of Tanshinone Analogues[J]. 中国化学, 2003, 21(7): 720-722. DOI: 10.1002/cjoc.20030210703 |
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| 作者姓名： | 阿吉艾克拜尔·艾萨 吕伟 蔡俊超 |
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| 作者单位： | Xinjiang Technical Institute of Physics & Chemistry，Chinese Academy of Sciences，Urumqi，Xinjiang 830011，China，Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 200031，China，Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 200031，China |
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| 摘 要： | 8, 8-Dimethyl-5, 6, 7,8-tetrahydrophenanthrene-3, 4-dione (3) and 8, 8-dimethyl-2- ( 1-hydroxy ethyl) -5,6, 7, 8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell fine as assayed by in vitro MTT method.
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| 关 键 词： | 合成 抗肿瘤活性 丹参酮类似物 白血病 8 8－二甲基－5 6 7 8－四氢化菲－3 4－二酮 8 8－二甲基－2－（1－羟基乙烷基）－5 6 7 8－四氢化菲－3 4－二酮 |
Synthesis and Antitumor Activity of Tanshinone Analogues |
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| AISA,Haji Akber LU,Wei CAI,Jun-ChaoXinjiang Technical Institute of Physics , Chemistry,Chinese Academy of Sciences,Urumqi,Xinjiang ,China. Synthesis and Antitumor Activity of Tanshinone Analogues[J]. Chinese Journal of Chemistry, 2003, 21(7): 720-722. DOI: 10.1002/cjoc.20030210703 |
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| Authors: | AISA Haji Akber LU Wei CAI Jun-ChaoXinjiang Technical Institute of Physics & Chemistry Chinese Academy of Sciences Urumqi Xinjiang China |
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| Affiliation: | AISA,Haji Akber LU,Wei CAI,Jun-ChaoXinjiang Technical Institute of Physics & Chemistry,Chinese Academy of Sciences,Urumqi,Xinjiang 830011,China Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031,China |
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| Abstract: | 8,8-Dimethyl-5,6,7, 8-tetrahydrophenanthrene-3, 4-dione (3) and 8,8-dhnethyl-2-(1-hydroxy ethyl)-5,6,7,8-tetrahydrophe-nanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell line as assayed by in vitro MTT method. |
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| Keywords: | synthesis tanshinone analogues |
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