Determination of limiting ionic mobilities and dissociation constants of some local anaesthetics. |
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| Authors: | M Polásek B Gas T Hirokawa J Vacík |
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| Institution: | Department of Physical and Macromolecular Chemistry, Faculty of Sciences, Charles University, Prague, Czechoslovakia. |
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| Abstract: | The limiting ionic mobilities and thermodynamic acid dissociation constants were calculated from isotachophoretic experiments for the local anaesthetics procaine, tetracaine, lidocaine, trimecaine, bupivacaine, cinchocaine, diperodone, diocaine, cocaine, psicaine-neu, tropacocaine, amylocaine, beta-eucaine and leucinocaine. The pH values at which the local anaesthetics with very similar limiting ionic mobilities can be isotachophoretically separated were determined from simulated mobility curves. The measuring apparatus employed a high-frequency contactless conductivity detector. |
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