A novel isocyanide-based three-component reaction: synthesis of highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives |
| |
| Authors: | Shaabani Ahmad Maleki Ali Moghimi-Rad Jafar |
| |
| Institution: | Department of Chemistry, Shahid Beheshti University, P.O. Box 19396-4716, Tehran, Iran. a-shaabani@cc.sbu.ac.ir |
| |
| Abstract: | A novel multi-component synthesis of highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives starting from simple and readily available inputs is described. Thus, simply stirring an ethanol solution of 2,3-diaminomaleonitrile, a ketone, and an isocyanide in the presence of a catalytic amount of p-toluenesulfonic acid provided highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives in good to excellent yields at ambient temperature. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
