Convenient synthesis of 5′-methyl-2′-desoxyuridines |
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Authors: | S. N. Mikhailov N. Sh. Padyukova K. I. Panov |
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Affiliation: | (1) Institute of Molecular Biology, Academy of Sciences of the USSR, 117984 Moscow |
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Abstract: | A convenient method has been developed for the synthesis of 5-methyl-2-desoxyuridines. Chlorination of 5-O-benzoyl-5-methyluridines with a mixture of Ph3P and CCl4 in DMF affords the 2-desoxy-2-chloro-derivatives, which are then reduced with tributyltin hydride. The crystalline 5-O-benzoyl-5-methyl-2-desoxyuridines were obtained in overall yields of 40–60%. In a similar way, 5-O-benzoyluridine has given 5-O-benzoyl-2-desoxyuridine.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 246–248, February, 1989. |
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