Biomimetic aerobic oxidation of amino alcohols to lactams |
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Authors: | Beneesh P Babu Yoshinori Endo Jan-E Bäckvall |
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Affiliation: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91, Stockholm (Sweden), Fax: (+46)?8-154-908. |
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Abstract: | The right path: N-Protected amino alcohols undergo aerobic and biomimetic oxidation to the corresponding lactams in the presence of a ruthenium catalyst and a combination of electron-transfer mediators under air. The reaction was used for the synthesis of five-, six-, and seven-, membered lactams and showed good tolerance to a number of N-protecting groups. |
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