Enantioselective formal synthesis of antitumor agent (+)-ottelione A |
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Authors: | Mi Young Lee Shuai Jiang Jae Yi Sim Do Hyun Ryu |
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Institution: | a Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Republic of Korea b Korea Basic Science Institute, 5St, Anam-Dong, Seongbuk-Gu, Seoul 136-701, Republic of Korea |
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Abstract: | The enantioselective formal synthesis of a natural antitumor product, (+)-ottelione A, was achieved through a catalytic enantioselective Diels-Alder strategy. These endeavors have led to the synthesis of a variety of synthetic analogues of this biologically potent natural product. |
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